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Morulae... in a spleen and liver?!

Throwback Wednesday! I posted this case in the Cyto Coffeehouse group back in 2018, and it's too good not to share again...


So, here I am, just cruising around this spleen/liver combo sample from a 9 yo Lab with fever, lethargy, joint effusion/pain, and thrombocytopenia. It wasn’t indicated to me why the spleen and liver were aspirated (no masses described), but as I’m looking around....I start to notice these little cuties! Once I saw one, I noticed them pretty frequently.


Morulae I’ve only personally seen morulae in neuts in blood smears and once in a joint effusion. So this was super fun to see in a spleen/liver sample!


Differentials for these are either Anaplasma phagocytophilum or Ehrlichia ewingii since those two organisms look the same on cytology. I suggested they do tick PCR (their SNAP was negative, but it can be negative in acute infections) to differentiate.


First 2 pics are liver, last 1 is spleen. Cool, huh?!


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